X. Long Zheng MD PhD

PubMed

• 8 citations
  ADAMTS13 or Caplacizumab Reduces the Accumulation of Neutrophil Extracellular Traps and Thrombus in Whole Blood of COVID-19 Patients under Flow.
  Noritaka Yada, Quan Zhang, Antonia Bignotti, Zhan Ye, X Long Zheng
  Thrombosis and Haemostasis. 2024-08-01
• 7 citations
  Targeting neutrophil extracellular trap accumulation under flow in patients with immune-mediated thrombotic thrombocytopenic purpura.
  Noritaka Yada, Quan Zhang, Antonia Bignotti, Sarah H Gralnek, Dennis Sosnovske
  Blood Advances. 2024-05-28
• 3 citations
  Mechanism underlying severe deficiency of plasma ADAMTS-13 activity in immune thrombotic thrombocytopenic purpura.
  X Long Zheng
  Journal of Thrombosis and Haemostasis. 2024-05-01

Journal Articles

• Understanding thrombotic microangiopathies in children  
  Joly BS, Zheng XL and Veyradier A, Inten Care Med, 1/24/2018
• Low Plasma ADAMTS13 Activity is Associated with Coagulopathy, Endothelial Cell Damage and Mortality after Severe Pediatric Trauma  
  Russell RT, McDaniel JK, Cao WJ, Shroyer M, Wagener BM, Zheng XL (corr. au.), JF Pittet, Thromb Haemost, 1/1/2018
• Mutations in Coagulation Factor VIII Are Associated with More Favorable Outcome in Patients with Cutaneous Melanoma  
  Ping Z., Soni A., Williams AL, Pham HP, Basu MK, and Zheng XL, TH Open, 1/1/2017
• Thrombotic Thrombocytopenic Purpura: Pathogenesis, Diagnosis, and Potential Novel Therapeutics  
  Saha M, McDaniel JK, Zheng XL, J Thromb Haemost, 1/1/2017
• Plasma ADAMTS13 activity and von Willebrand factor antigen and activity in patients with subarachnoid hemorrhage  
  Kumar M, Cao WJ, McDaniel JK, Pham HP, Raju D, Nawalinski K, Frangos S, Kung S, Zager E, Kasner SE, Levine JM, Zheng XL, Thromb Haemost, 1/1/2017
• Conformational quiescence of ADAMTS13 prevents proteolytic promiscuity: comment  
  Cao WJ, and Zheng XL, J Thromb Haemost, 1/1/2017
• Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A  
  Nguyen GN, George LA, Siner JI, Davidson RJ, Zander CB, Zheng XL, Arruda VR, Camire RM, Sabatino DE, J Thromb Haemost, 1/1/2017
• Platelet transactivation by monocytes promotes thrombosis in heparin induced thrombocytopenia  
  Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M, Rauova L, Blood, 1/1/2016
• Acquired autoimmune thrombotic thrombocytopenic purpura in a case of severe haemophilia A  
  Williams LA, Drwiega JC, Cao W, Pham HP, Bertoli LF, and Zheng XL, Haemophilia, 1/1/2016
• High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome  
  Casina VC, Hu W, Mao JH, Lu RN, Hanby HA, Pickens B, Kan ZY, Lim WK, Mayne L, Ostertag EM, Kacir S, Siegel DL, Englander SW, Zheng XL, Proc Natl Acad Sci USA, 1/4/2015
• ADAMTS13 and VWF interactions  
  Zander C. Cao WJ, Zheng XL, Curr Opin Hematol, 1/1/2015
• Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease  
  Lu RN, Yang S, Wu HM, Zheng XL, J Thromb Haemost, 1/1/2015
• ADAMTS13 and its variants promote angiogenesis via upregulation of VEGF and VEGFR2  
  Lee M1, Keener J, Xiao J, Zheng XL, Rodgers GM, Cell Mol Life Sci, 1/1/2015
• Carboxyl-terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large VWF string formation under flow in a free thiol-dependent manner  
  Bao J., Xiao J., Mao J., and Zheng X.L., Arteroscler Thromb Vascul Biol, 1/1/2014
• Biochemistry and physiological function of ADAMTS7  
  Hanby H.H. and Zheng X.L., Adv Biochem, 1/1/2013
• Structure-function and cofactor-dependent regulation of ADAMTS13 protease  
  Zheng X.L., J Thromb Hemost, 1/1/2013
• ADAMTS13, TTP, and Beyond (Editorial)  
  Zheng X.L., Hereditary Genet, 1/1/2012
• Gain-of-function ADAMTS13 variants that are resistant to inhibition by autoantibodies in patients with acquired idiopathic thrombotic thrombocytopenic purpura  
  Jian C., Xiao J., Gong L., Skipwith C.G., Jin S-Y, Kwaan H-C, and Zheng X.L., Blood, 1/1/2012
• Genetic ablation of Adamts13 gene dramatically accelerates the early atherosclerosis in a murine model  
  Jin S-Y., Tohyama J., Bauer R.C., Cao N.N, Rader D.J., and Zheng X.L., Thromb Vasc Biol, 1/1/2012
• Essential Domains of ADAMTS13 Metalloprotease Required for Modulation of Arterial Thrombosis  
  Xiao J., Jin S-Y., Xue J., Sorvillo N., Voorberg J., and Zheng X.L., Arterioscler, 1/1/2011
• A Shear Based Assay for Assessing Plasma ADAMTS13 Activity in Patients With Thrombotic Thrombocytopenic Purpura  
  Han Y., Xiao J., Falls E., and Zheng X.L., Transfusion, 1/1/2011
• Analysis of Morphology of Platelet Aggregates Formed on Collagen Under Laminar Blood Flow  
  Colace T., Falls E,. Zheng X.L., Diamond S.L., Ann Biomed Eng, 1/1/2011
• Toward A Definition of "Fresh" Whole Blood: An In-vitro Characterization of Coagulation Properties in Refrigerated Whole Blood for Transfusion  
  Jobes,D. Wolfe, Y. O'Neill,D. Calder, J. Jones, L. Sesok-Pizzini,D, and Zheng X.L., Transfusion, 1/1/2011
• Amino acid residues Arg659, Arg660 and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor  
  Jin S.Y., Skipwith C.G., and Zheng X.L., Blood, 1/1/2010
• ADAMTS13 testing-Why bother?  
  Zheng X.L., Blood, 1/1/2010
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Books/Book Chapters

• Transfusion Medicine, Apheresis, and Hemostasis: Review Questions and Case Studies 
  Chapter: Interpretation of data 
  Zheng XLEditors: Huy P. Pham, Lance A. Williams III.Edition 1st,2017
• ADAMTS13: Biology and Disease 
  Chapter: Structure-function of ADAMTS13 
  Zheng XLEditors: Rodgers.Springer2015

Abstracts/Posters

• African American Race Is Associated with Decreased Relapse-Free Survival in Immune Thrombotic Thrombocytopenic Purpura
  X. Long Zheng, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Plasma Levels of Histone-DNA Complex and Cell-Free DNA Predict Mortality in Patients with Immune Thrombotic Thrombocytopenic Purpura
  X. Long Zheng, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Longitudinal Assessment of Plasma ADAMTS13 Biomarkers Helps Predict Recurrence of Immune Thrombotic Thrombocytopenic Purpura
  X. Long Zheng, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

• A journey from Obstetrician to pathologist 
  1/1/2018
• TMA: from zebrafish to men 
  1/1/2018
• HUS: Dual Presentation Diagnosis and Treatment 
  Westchester Medical Center, Valhalla, NY - 1/1/2018
• aHUS: Evidence Based Guidelines in Therapeutic Apheresis 
  Dallas, TX - 1/1/2018
• TTP: from bench to bedside 
  San Francisco, CA - 1/1/2018
• Diagnosis and differential diagnosis of thrombotic microangiopathy 
  Los Angeles, CA - 1/1/2017
• TMA-from bench to bedside 
  UNC-Chapel Hill, NC - 1/1/2017
• Atypical hemolytic uremic syndrome 
  Nashville, TN - 1/1/2017
• Pathogenesis of thrombotic thrombocytopenic purpura: lesson from zebrafish to men. 
  China - 1/1/2017
• ADAMTS13, TTP, and beyond 
  Fort Lauderdale, FL - 1/1/2017
• A Novel Zebrafish Model of Thrombotic Thrombocytopenic Purpura (TTP) Created by CRISPR/Cas, 
  1/1/2017
• Thrombotic thrombocytopenic purpura (TTP) - from Bench to Bedside 
  Montgomery, AL - 1/1/2017
• Thrombotic thrombocytopenic purpura-diagnosis, mechanism, and novel therapeutics 
  University of Michigan, Ann Arbor, MI - 1/1/2016
• What do we know about TTP? 
  Hospital of University of Alabama at Birmingham, AL - 1/1/2016
• Interaction between VWF and ADAMTS13 under flow 
  Montpellier, France - 1/1/2016
• Novel therapeutics for acquired autoimmune TTP 
  Stoweflake, VT - 1/1/2016
• Hemostasis, hematology, and transfusion medicine research (RED) club, ADAMTS13, beyond TTP 
  1/1/2016
• New Horizon-Discovery in TTP 
  Memphis, TN - 1/1/2016
• Novel therapeutics for acquired thrombotic thrombocytopenic purpura 
  Birmingham, AL - 1/1/2016
• Novel therapeutics for acquired TTP 
  University of Alabama at Birmingham, AL - 1/1/2015
• Molecular Mechanism and Novel Therapeutics of Thrombotic Thrombocytopenic Purpura 
  Cleveland Clinic, OH - 1/1/2014
• Thrombotic Microangiopathy-Molecular Mechanism and Novel Therapeutics 
  Vanderbilt University, Nashville, TN - 1/1/2014
• Structure-function and regulation of ADAMTS13 protease 
  Amsterdam, Netherland - 1/1/2013
• Proteolysis of von Willebrand factor by ADAMTS13 under fluid shear stress. 
  Amsterdam, Netherlands - 1/1/2013
• ADAMTS13 in thrombotic thrombocytopenic purpura 
  Peking University Renming Hospital, Beijing, China - 1/1/2012
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